Patogenesis. Sindrom antibodi antifosfolipid merupakan gangguan autoimun yang ditandai dengan antibodi dalam sirkulasi yang melawan fosfolipid membran. SAPPORO CRITERIA Sindrom antifosfolipid haruslah memenuhi kriteria yang diputuskan oleh para ahli pada simposium internasional ke-8 tentang antibodi. Posts – See Instagram photos and videos from ‘antifosfolipid’ hashtag. ➡ ️Antifosfolipid sindrom və hamiləlik⬅ Antifosfolipid sindrom venoz və ya arterial .

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Anti-thrombin Lupus anticoagulant Coeliac disease: There are 3 distinct APS disease entities: The patient on initial screening will typically have been found to have a prolonged APTT that does not correct in an Antiphospholipid Syndrome Sindrom Antibodi Antifosfolipid. Thus, anti-annexin A5 antibodies increase phospholipid-dependent coagulation steps.

This page was last edited on 17 Novemberat This is tested for by using a minimum of two coagulation antifosfolipjd that are phospholipid-sensitive, due to the heterogeneous nature of the lupus anticoagulant antibodies.

The increased risks of recurrent miscarriageintrauterine growth restriction and preterm birth by antiphospholipid antibodies, as supported by in vitro studies, include decreased trophoblast viability, syncytialization and invasion, deranged production of hormones and signalling molecules by trophoblasts, as well as activation of coagulation and complement pathways.

D ICD – The primary mission of APS ACTION is to prevent, treat, and cure antiphospholipid antibody aPL associated clinical manifestations through high quality, multicenter, and multidisciplinary clinical research.


Antiphospholipid syndrome

Antiphospholipid syndrome is an autoimmune diseasein which “antiphospholipid antibodies” anticardiolipin antibodies and lupus anticoagulant react against proteins that bind to anionic phospholipids on plasma membranes. Antiphospholipid syndrome is tested for in the laboratory using both liquid phase coagulation assays lupus anticoagulant and solid phase ELISA assays anti-cardiolipin antibodies.

Antiphospholipid syndrome often requires treatment with anticoagulant medication such as heparin to reduce the risk of further episodes of thrombosis and improve the prognosis of pregnancy. In rare cases, APS leads to rapid organ failure due to generalised thrombosis; this is termed ” catastrophic antiphospholipid syndrome ” CAPS or Asherson syndrome and is associated with a high risk of death.

Anticoagulation appears to prevent miscarriage in pregnant women. The American Journal of the Medical Sciences.

Antiphospholipid syndrome – Wikipedia

Presence of genetic thrombophilia may determine the need for anticoagulation therapy. Archived copy as title Infobox medical condition new All articles with unsourced statements Articles with unsourced statements from October Articles with antifosolipid statements from January The relationship of APA to thrombosis and pregnancy loss is unknown. APS provokes blood clots thrombosis in antifosvolipid arteries and veins as well as pregnancy-related complications such as miscarriagestillbirthpreterm deliveryand severe preeclampsia.

They published the first papers in In pregnant women affected by APS, there is an increased risk of recurrent miscarriageintrauterine growth restrictionand preterm birth.

Antiphospholipid Syndrome (Sindrom Antibodi Antifosfolipid)

Micrograph showing an advanced thrombotic microangiopathyas may be seen in ALPA syndrome. Archived PDF from the original on Annexin A5 forms a shield around negatively charged phospholipid molecules, thus reducing their availability for coagulation.


Like many autoimmune diseasesit is more common in women than in men. Thus, anti-protein S antibodies decrease protein C efficiency. Other common findings, although not part of the APS classification criteria, are low platelet countheart valve diseaseand livedo reticularis.


Antiphospholipid syndrome was described in full in the s, by Nigel Harris and Aziz Gharavi. Coagulopathies Rheumatology Autoimmune diseases Neurological disorders Obstetrics Syndromes affecting blood Syndromes antifisfolipid the nervous system.

The Johns Hopkins Lupus Center. There is an additional elevated risk of adrenal gland bleeds leading to Waterhouse—Friderichsen syndrome Neisseria meningitidis caused primary adrenal insufficiency.

From Wikipedia, the free encyclopedia. Majalah Kedokteran Indonesia,46 8 Specialty Rheumatology Antiphospholipid syndrome or antiphospholipid antibody syndrome APS or APLSis an autoimmunehypercoagulable state caused by antiphospholipid antibodies.

The APTT plus This will require adrenal steroid replacement treatment for life. Retrieved from ” https: Eindrom syndrome APS is a disorder of recurrent vascular thrombosis, pregnancy losses and thrombocytopenia associated with persistently elevated levels of antiphospholipid antibodies APA.