INTRATUMOR HETEROGENEITY AND BRANCHED EVOLUTION REVEALED BY MULTIREGION SEQUENCING PDF

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing. / Gerlinger, Marco; Rowan, Andrew J.; Horswell, Stuart; Larkin, James;. Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion . intratumor heterogeneity, we performed exome sequencing, chromosome. Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing N Engl J Med ;–92Re: Single-cell Exome Sequencing Reveals.

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Gene-expression signatures of good and poor prognosis were detected in different regions of the same tumor. A comment on this article appears in ” Intratumor heterogeneity and branched evolution. You hereby agree to indemnify and keep indemnified F, its affiliates, contractors and agents from and against any and all losses including without limitation direct, indirect and consequential losscosts, claims, damages or expenses of whatever nature and howsoever caused arising directly or indirectly from any breach of these Terms and Conditions or arising from the Material posted on this website or content contained in any email sent using the facilities provided by the website by you including without limitation as a result of any infringement of any intellectual property or other proprietary rights, libel, defamation, obscenity or the Material being otherwise unlawful.

Andrew ; Swanton, Charles. Breast cancer brain metastases show increased levels of genomic aberration based homologous recombination deficiency scores relative to their corresponding primary tumors Research output: CitePeer Related Articles http: View graph of relations.

METHODSTo examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy profiling on multiple spatially separated samples obtained from primary renal carcinomas and associated metastatic sites.

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

Gene-expression signatures of good and poor prognosis were detected in different regions of the same tumor. Gene-expression multiregin of good and poor prognosis were detected in different regions of the same tumor. See N Engl J Med. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

The New England Journal of Medicine10 Funded by the Medical Research Council and others. Gerlinger, Marco ; Rowan, Andrew J. Intratumor heterogeneity was observed for a mutation within an autoinhibitory domain of the mammalian target of rapamycin mTOR kinase, correlating with S6 and 4EBP phosphorylation in vivo and constitutive activation of mTOR kinase activity in vitro.

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Allelic composition and ploidy profiling analysis revealed extensive intratumor heterogeneity, with 26 of 30 tumor samples from four tumors harboring divergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors. Mutational intratumor heterogeneity was seen for multiple tumor-suppressor genes converging on loss of function; SETD2, PTEN, and KDM5C underwent multiple distinct and spatially separated inactivating mutations within a single tumor, suggesting evklution phenotypic evolution.

Don’t have an account? Computational prediction of neoantigens: We characterized the consequences of intratumor heterogeneity using immunohistochemical analysis, mutation functional analysis, and profiling of messenger RNA expression.

Intratumor heterogeneity was observed for a mutation within an autoinhibitory domain of the mammalian target of rapamycin mTOR kinase, correlating with S6 and 4EBP phosphorylation in vivo heterkgeneity constitutive activation of mTOR kinase activity in vitro.

Address reprint requests to Dr. Funded by the Medical Research Council and others.

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Abstract Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples.

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Gene-expression signatures of good and poor prognosis were detected in different regions of the same tumor. Intratumor heterogeneity was observed for a mutation within an autoinhibitory domain of the mammalian target of rapamycin mTOR kinase, correlating with S6 and 4EBP phosphorylation in vivo and constitutive activation of mTOR kinase activity in vitro.

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Allelic composition and ploidy profiling analysis revealed extensive intratumor heterogeneity, with 26 of 30 tumor samples from four tumors harboring divergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors.

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Register for day free trial Registration is free and only takes a moment, or subscribe for unlimited access. To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy profiling on multiple spatially separated samples obtained from primary renal carcinomas and associated metastatic sites.

Allelic composition and ploidy profiling analysis revealed extensive intratumor heterogeneity, with 26 of 30 tumor samples from four tumors harboring divergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors. METHODSTo examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy profiling on multiple spatially separated samples obtained from primary renal carcinomas and associated metastatic sites.