Abstract. BELLO, Ariel et al. Splenic marginal zone lymphoma. Acta Med Colomb [online]. , vol, n.1, pp ISSN Non-Hodgkin. Splenic marginal zone lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma characterized by abnormal clonal proliferation of mature B- lymphocytes with. Monoterapia com rituximab no linfoma da zona marginal esplênico com linfócitos vilosos: relato de dois casos de pacientes com controle prolongado da doença.

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Are you a health professional able to prescribe or dispense drugs? Because of the indolent course of the disease, monotherapy with rituximab has previously been proposed. Splenic marginal zone lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma characterized by abnormal clonal proliferation of mature B-lymphocytes with involvement in the spleen, bone marrow and, frequently, the blood.

LEZM – Linfoma Esplénico de la Zona Marginal

A previously healthy year-old man was diagnosed with SMZL in April immunophenotype of circulating lymphocytes that was compatible with SMZL with villous lymphocytes. Marginal zone B-cell lymphoma: Median response duration was 21 months range 4 to 37 months.

Frecuente anemia y trombocitopenia. For all other comments, please send your remarks via contact us. The molecular biological characteristics are, in general, well defined in small cell B-cell lymphomas, such as chromosomal translocations involving the immunoglobulin heavy chain genes and the Bcl-2 gene or Cyclin D1 gene.

Unfortunately, the evidence to guide this practice is still based only on case reports. CD 5- CD 10Otros: We report the case of a year-old man with erythematous-violaceous plaques and nodules. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin’s lymphoma. The role of rituximab as maintenance therapy, in order to prolong the time that elapses until progression occurs, still needs to be confirmed.


Detailed information Professionals Review article Deutsch You can change the settings or obtain espleico information by clicking here. Hepatitis C virus and autoimmune manifestations, such as autoimmune hemolytic anemia and autoimmune thrombocytopenia, could be associated.

Linfoma esplénico de la zona marginal:

A clinical comparison of nodal and mucosa-associated lymphoid tissue types. Specialised Social Services Eurordis directory. The median clinical remission interval was 46 months.

After treatment, all patients had a complete resolution of splenomegaly along with restoration of their blood counts. The median number of CD20 molecules per cell was 69 x 10 3.

Among the complete responders seven patients had also a molecular remission. Analysis of immunoglobulin genes in splenic marginal zone lymphoma suggests ongoing mutation. Inmunocitoma con presencia de cuerpos de Dutcher nucleares flecha.

The treatment was well tolerated. The BCL6 gene in B-cell lymphomas with 3q27 translocations is expressed mainly from the rearranged allele irrespective of the partner gene.

Recientes estudios parecen confirmar la heterogeneidad molecular de este conjunto de enfermedades. Am J Surg Pathol.

Only comments written in English can be processed. Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations.

Procesos linfoproliferativos no Hodgkin de células B

RT PCR para t 11; CiteScore measures average citations received per document published. Nonimmunoglobulin gene hypermutation in germinal center B cells.

New approach to classifying non-Hodgkin’s lymphomas: Splenic marginal zone B-cell lymphomas: Two further cycles of rituximab were administered, three and six months after remission. In relapsed patients, the median interval between diagnosis and treatment was 6 month range: Cutaneous presentation of follicular lymphomas.


References of trials included in systematic review Reference 2 in. Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. Splenic lymphoma with villous lymphocytes: Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted.

A revised European-American classification of lymphoid neoplasms: Translocation t 11;14 q13;q32 in martinal lymphoid disorders. Health care resources for this disease Expert centres Diagnostic tests 59 Patient organisations 45 Orphan drug s It is still unclear whether these patients should undergo cytotoxic chemotherapy, considering they have now a relapsed lymphoma which is lz more aggressiveor whether they should be spared from treatments of greater toxicity, given that their disease usually develops with a more indolent course, even when it recurs.

Print Send to a friend Export reference Zonq Statistics. The aim of any lymphoma classification is to provide an international language allowing communication. The indications for treatment were the same as those used for patients with chronic lymphocytic leukemia.

Si continua navegando, consideramos que acepta su uso. Es un tumor indolente, no curable. Ocasional presencia discreta de componente M en suero.

The diagnosis was established using standard criteria.